Everton were beaten 2-1 by the Hammers in added time, having been denied a penalty claim, a week after defeat to Liverpool by the same score, and again in extra time with a goal and another penalty shout earlier chalked off.
This result at the London Stadium was a really hard loss to take, and it was made even worse given that there was again another hugely irritating VAR decision that went against the away team during the game.
These repetitive controversies have become an almost weekly occurrence for Toffees supporters and create a relentless sense of frustration, anger, and disbelief at the pattern of decisions that go against their team.
To be fair, many other Premier League clubs could point to something similar, but it does feel as though Everton are on the wrong end of these moments more than most.
While last weekend's offside decision that ruled out Illman Ndiaye's goal might have been justified, it is very hard to see how the Blues' penalty claim was turned down against West Ham.
It looked a stonewall and clear handball as the West Ham player batted the ball away, and given that so many other such examples with far less clear-cut circumstances are given, how was that penalty not awarded?
I do not want to make assumptions about why this is happening; there seems to be a clear slant to these rulings in ways that constantly hurt the Blues. That is all I will say.
In a wider sense, though, something has to be done about these erratic and troublingly inconsistent decisions, as it is ruining the game and potentially altering results in ways that are significant for the sides involved.
In truth, it is possible to argue that even without the intervention of officialdom, Everton might still have lost the match. They were poor in the first half and gave away a soft set-piece goal while once more looking toothless up front.
Thierno Barry started in place of the injured Beto, and he had another bad game, failing to offer a serious threat. Although he tries hard, he appears to be a bust of a centre-forward, and there are serious questions about whether he has a future at the Hill Dickinson.
Everton also looked worryingly vulnerable again at set-pieces and gave up the first goal from such a situation, just as they did against Liverpool.
After Saturday's defeat and looking at the league table with the Blues in eleventh, it seems increasingly unlikely the Toffees will qualify for European football next season.
Perhaps that might be a blessing in disguise for the short term, given how playing twice a week can become a real problem for teams without the necessary strength in depth. It is a sort of Catch-22 situation, though, as qualifying would help player recruitment.
Once more, then David Moyes has several significant issues that he has to address in this summer's upcoming transfer window if his team is to push on and sustain a challenge at the top end of the Premier League.
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