The Toffees have been dealt a few blows to their lineup, so David Moyes will have a tough trick on his hands for the weekend fixture.
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Two more injuries plus players missing on international duty are leaving the squad as threadbare as ever.
With AFCON beginning next week, two key players for Everton will be away for a while. David Moyes must use all available players, including his big summer signing.
The London ground has not been kind to Everton in recent years, but David Moyes will need to figure out how to line up his side for the best outcome.
Most teams in the Premier League will be without the services of several players. Everton's opponents during that stretch are no different.
A recent ruling by the football governing body has made it clear there is no room for budging.
Like Old Trafford and the Vitality Stadium, the Toffees will look to break another extended run of futility on Saturday.
Earlier reports indicated that the club was interested in retaining James Garner, and now the two sides appear to be closing in on a deal.
Everton's roster appears to be thinning every week, but they still must find a way to field a team.
The summer signing has been a massive addition to the Everton side, and he's now endearing himself to the supporters even more.
The news gives clubs, including Everton, a clear indication of when players will leave for international camps.
Coming off the beating the Toffees took on Saturday, the response was excellent and much needed.
Everton will travel to the Vitality Stadium to take on the Cherries on a rare Tuesday night matchup.
The Toffees are in a solid place this season, but clearly have positions that need to be filled.
Unlike the first few weeks of the season, injuries and suspensions are now making this exercise much more complicated.
The Senegal midfielder was sent off at Old Trafford for an altercation with his teammate, but Everton won the match anyway.
The match was low on style points, but there's little doubt that Everton were the better team on the day.
The international break is over, and so the long run of matches until the Spring begins with a Monday night trip to Manchester United.
The Scot has played for well for club and country in recent years, but a move back to the Premier League, at least to Everton, cannot be in the cards.
The midfielder is another key player who will miss an extended period during the upcoming tournament.